anti TNF-α monoclonal antibody
medications,adverse effects, mechanism of resistance

etanercept→ RA, psoriasis, AS
infliximab, adalimumab→ RA, IBD, psoriasis, AS

predisposition to infection including reactivation of TB(since TNF is important in granuloma formation and stabilization)

☆antitumor antibodies can develop against adalimumab, infliximab (not common with etanercept)

pharmacology immunology UWorld