sulfonylureas
mechanism,
1st, 2nd geng drugs, adverse effects

close K+ channel in pancreatic β cell membrane→ cell depolarizes→ insulin release via ↑Ca influx

1st→ chlorpropamide, ☆tolbutamide
disulfiram like syndrome

2nd→ glipizide, ☆glyburide
hypoglycemia

endocrinology pharmacology UWorld