rapid acting insulin

physiologic insulin secretion

1-2 hr peak
no LAG
Lispro, Aspart, Glulisine

(→ regular(2-4hr) available ☆iv, im → NPH(4-12hr)→detemir(3-9hr, lasts up to 24hr)→)

glarGINE→no peak(long acting, lasts about 24hr)

insulin degludec, concentrated glargine with duration of action>24hr

physiologic insulin secretion can be approximated by a combination of ☆long-acting and rapid-acting insulin analogs (ie, basal-bolus regimen).
(glargine once daily plus lispro before each meal)

endocrinology 卒試 UWorld