・tuberculoid leprosy
least severe, intact cell mediated immunity, ☆hypopigmentation, hair follicle loss
☆develop a strong Th1 mediated response(IL-2,12, IFN-γ)→+lepromin skin test
・lepromatous leprosy
most severe, weak CMI, plaque like hypopigmentation, leonine facies, regional anesthesia, testicular destruction, and blindness
Th2 cytokine profile(IL-4,5,10)→-lepromin skin test
*M leprae groms best at temperatures below core body temperatures
microbiology
UWorld
Optimized studying based on the forgetting curve vastly improves memorization. - What is reminDO?
Memorize
