①Mutations leading to underexpression of KatG(which encodes ☆bacterial intracellular catalase peroxidase needed to convert INH to active metabolite)
②modification of protein target binding site for isoniazid
→ ☆selective survival of bacterial cells
→ makes it necessary to treat active tuberculosis with combined multiple antibiotics(+RFN+EB(SM)±PZA)
INH monotherapy is used for positive PPD and negative X-ray
Mutations reduce drug binding to RNA polymerase.
microbiology
UWorld
Optimized studying based on the forgetting curve vastly improves memorization. - What is reminDO?
Memorize