patiromer
mechanism, clinical use, adverse effecta nonabsorbable cation exchange resin that binds colonic potassium in exchange for calcium, trapping potassium within the resin where it is then excreted in the feces.
often used for treatment of ★chronic hyperkalemia. (however, onset of action takes several hours, so it is not recommended as monotherapy in acute hyperkalemia)
GI disturbance, hypercalcemia, hypokalemia, hypomagnesemia
the reason why phenytoin trigger neural tube defectchronic phenytoin use changes PH in the gut into 10-12, which reduces folate uptake(optimal PH for folate is 5〜5.5) pharmacologyembryologyOBGY HirotoShishido
original combination chemotherapy for Hodgkin lymphomacan be used for the patients who relapse or have allergies to ABVD
three types of chronic gout drugsxanthine oxidase inhibitors
-allopurinol
(oxypurinol)
-feboxostat
uricosuric medication
-probenecid
-sulfinpyrazone(not used in Japan)
→☆dosage adjustment for penicillin
(because organic anion transporter(OAT) is inhibited in the proximal convoluted tubule, and inhibits secretion of penicillin)
HIV prophylaxis for pregnancy, adverse effectsZidovudine(ZVD) (NRTIs)
ZIDOvudine→decreased risk of FETAL(児童)transmission(indicated w/ pregnancy)
☆bone marrow suppression(can happen to NRTIs but the most common in zidovudine), peripheral neuropathy, and specifically, anemia microbiologypharmacology HirotoShishido
COX non selective NSAIDs indicationssame as aspirin+gout,PDA(indometacin),(postoperative)severe acute pain(ketorolac) pharmacology HirotoShishido
