chloride shift
The additional CO2 enters the RBCs, and carbonic anhydrase catalyzes a reaction with water to form carbonic acid (H2CO3), which then dissociates into H+ and HCO3-. The hydrogen ions are buffered by the deoxyhemoglobin, while the HCO3- diffuses out of the RBCs in exchange for Cl-. This is called the chloride shift.
respiratory
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