inhibit the production of THF via ↓dihydrofolate reductase
☆ALL, lymphoma, choriocarcinoma, sarcoma
ectopic pregnancy, RA, IBD, psoriasis
myelosuppression, ☆★hepatotoxicity, ☆mucositis, ★pulmonary fibrosis = idiosyncratic (ie, not dose dependent) reaction, folate deficiency, nephrotoxicity
☆reversible with leucovorin(N5-formyl-THF)
on the other hand, leucovorin can potentiate the toxicity of fluorouracil
pharmacology
UWorld
UWorld step2CK
Optimized studying based on the forgetting curve vastly improves memorization. - What is reminDO?
Memorize
