A patients presents insidiously with memory loss of recent events.
executive dysfunction+visuospatial impairment early in the disease course,
language and behavioral abnormalities often later
☆neuritic(senile) plaques→ in gray matter: extracellular β-amyloid core; may cause amyloid angiopathy→intracranial hemorrhage
(no α secretase
neurofibrillary tangles→ intracellular, hyperphosphorylated tau protein = insoluble cytoskeletal elements; number of tangles correlates with degree of dementia.
neurology
UWorld
Optimized studying based on the forgetting curve vastly improves memorization. - What is reminDO?
Memorize
