①cytotoxic edema begins hours after the ischemic injury. The ☆failure of ATP-dependent ion pumps leads to the accumulation of intracellular Na+ and water in neural and glial cells despite an intact blood-brain barrier.
②Vasogenic edema follows 24-48 hours later, when the release of inflammatory mediators disrupts the tight junctions of the blood-brain barrier, allowing proteins (eg, albumin) and water to enter the interstitial space.
☆neoplastic lesion can also disrupt
BBB
neurology
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