Trypsin can serve as its own inhibitor by cleaving active trypsin molecules at a second site, rendering them inactive.
(Serine peptidase inhibitor Kazal-type 1 (SPINK1) is secreted by pancreatic acinar cells and functions as a trypsin inhibitor)
Hereditary pancreatitis results from mutations involving the ☆trypsinogen or SPINK1 gene. The most common mutation leads to the production of abnormal trypsin that is ☆not susceptible to inactivating cleavage by trypsin.
gastrointestinal
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