congenital variant(AR)=lactase deficiency <acquired variant (eg. Crohn disease, infectious enteritis, ☆giardiasis)
the fermentation of undigested lactose by gut bacteria→ production of short-chain fatty acid→ ☆acidify the stool (decreased stool pH)
→hydrogen gas is also produced, leading to ◯increased breath hydrogen content
→☆elevated stool osmolality
gastrointestinal
biochemistry
UWorld
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