Small amounts of androgens continue to be produced in the ovaries and adrenal glands after menopause. In obese women, these androgens (eg, androstenedione) are readily converted to estrogens (eg, estrone) by the aromatase enzyme found in adipose tissue.
However, ovarian progesterone production remains low; therefore, the unopposed estrogen causes unregulated endom etrial proliferation and subsequent endometrial hyperplasia.
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