(Prion proteins are found in both neuronal and non-neuronal brain cells and normally existin an alpha-helical structure (PrPC))
Prion disease occurs after a domain in this protein undergoes a conformation change ☆from an alpha helix into beta-pleated sheet isoform (PrPSc [scrapie]), which ☆confers the ability to induce similar conformational changes in other proteins.
☆sponge-like vacuolated neurons in gray matter
neurology
UWorld
Optimized studying based on the forgetting curve vastly improves memorization. - What is reminDO?
Memorize
