The alpha subunit of the active G protein initially stimulates phospholipase C, which catalyzes the breakdown of membrane-bound inositol phospholipids into 2 second messenger products
– inositol triphosphate (IP3) and diacylglycerol (DAG).
IP3 produces most of its effects by ☆releasing stored calcium from the smooth endoplasmic reticulum.
DAG activates protein kinase C, which phosphorylates downstream regulatory proteins and transcription factors.
biochemistry
pharmacology
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