colitis associated vs sporadic colorectal cancer
(age, origin, location, number, histology, mutation)

Younger (age 40-55)
Flat(nonpolypoid) lesions
Proximal > distal (particularly with CD)
☆Multifocal
Mucinous and/or signet ring cells
Poorly differentiated
Early p53 mutation and late APCgene mutation


Older (age >60)
Polypoid lesions
Distal > proximal
Singular
Rarely mucinous
Well differentiated
Early APC gene mutation and late p53 mutation

gastrointestinal UWorld