cyclosporine(binds cyclophilin)
★tacrolimus(binds FK506 binding protein,FKBP)
both prevent IL-2 transcription
dose and duration dependent ☆rise in BUN and creatinin levels due to renal arteriolar (both afferent and efferent) vasoconstriction (☆★obliterative vasculopathy) which can lead to systemic hypertension
pharmacology
UWorld SIM2
UWorld step2CK
Optimized studying based on the forgetting curve vastly improves memorization. - What is reminDO?
Memorize 1
