management for transient ischemic attack(TIA)Secondary prevention of future stroke includes antiplatelet agents (eg, aspirin, clopidogrel) to prevent thrombus formation and ☆statin therapy (HMG-CoA reductase inhibitor; eg, atorvastatin, rosuvastatin) to reduce atherosclerotic plaque formation. Lifestyle modifications (eg, exercise, tobacco cessation) are also recommended. neurologyUWorld May 24, 2020, 3:25 AM HirotoShishido
prenatal screening for group B streptococcus
characteristics of the bacteriaGBS colonization by vaginal-rectal culture at 35-37 weeks gestation is recommended to identify colonized woman who require ★intrapartum penicillin/ampicillin to prevent neonatal GBS sepsis, pneumonia and meningitis
women with heavy colnization (eg. asymptomatic bacteriuria) needs ampicillin (★)regardless of screening status or rectovaginal culture results
hypothyroidism and T3synthetic T3 (liothyronine) is not recommended for the routine treatment of hypothyroidism, as it has a short half-life and patients can experience wide fluctuations in plasma T3 levels
orexin receptor antagonist☆raMELteon
→used for insomnia
☆with the lowest side effect burden in older adults
suvOREXANT
→ OREXin(hypocretin) ANTagonist
recommended in patients with liver disease, limited physical dependance pharmacologyUWorld Mar 22, 2020, 9:41 AM HirotoShishido
medication for weight loss
mechanism, adverse effects・orlistat
inhibit gastric and pancreatic lipase
(significant) GI side effect→ abdominal pain, flatulence, fat soluble vitamin deficiency
diffrentiate between folate and vitamin B12 deficiency↑ homocysteine in both
☆↑ methylmalonic acid only in cobalamin deficiency(cobalamin=cofacter for methylmalonyl CoA mutase)
(methylmalonyl CoA is converted to succinyl CoA with the cofactor vitamin B12. If there is not enough vitamin B12 present, methylmalonyl CoA is alternatively converted to methylmalonic acid) hematologyUWorld Jun 14, 2019, 1:49 AM HirotoShishido
