zinc-finger motifsthe most commonly identified DNA-binding domain in humans
Zinc-finger motifs are composed of chains of amino acids bound together around a zinc atom via linkages with cysteine (and sometimes histidine) residues. This forms a stable, finger-shaped structure containing 2 antiparallel β- strands and an α- helix.
Many ☆transcription factors(→ intracellular receptors) use multiple zinc-finger motifs to recognize specific genes and alter their activity. endocrinologybiochemistryUWorld Jun 28, 2020, 9:16 AM HirotoShishido
which reaction in the glycolysis does erythrocyte bypassbypass the conversion of 1,3-bisphosphoglycerate into 3-phosphoglycerate(normally produce ATP) using phoglycerate mutase
developmental delay in lysosomal strage diseaseTay sachs disease (hexosaminidase A)
Krabbe disease (galactocerebrosidase)
Hurler, Hunter disease biochemistry Jun 24, 2020, 5:18 AM HirotoShishido
what enzyme is used for metabolism of triglyceride to produce glucose(gluconeogenesis)☆glycerol kinase
glycerol is secreted into circulation from adipose tissue and transported to the liver, where it's phosphorylated to glycerol-3-phosphate by glycerol kinase biochemistryUWorld Jun 24, 2020, 4:23 AM HirotoShishido
enzyme for transamination reaction☆pyridoxine(vB6)
※All AAs (except threonine and lysine) undergo transamination at some point in their catabolism biochemistryUWorld Jun 24, 2020, 4:02 AM HirotoShishido
adrenoleukodystrophyX-linked recessive disorder of β-oxidation due to mutation in ABCD1 gene VLCFA buildup in adrenal glands, white (leuko) matter of brain, testes.
Progressive disease that can lead to adrenal gland crisis, coma, and death. biochemistry Jun 23, 2020, 8:14 AM HirotoShishido
I cell diseasedefect in N-acetylglucosaminyl-1-phosphotransferase→
failure of the Golgi to phosphorylate mannose residues (mannose-6-phosphate) on glycoproteins→
proteins are secreted extracellularly rather than delivered to lysosomes.
Results in coarse facial features, gingival hyperplasia, clouded corneas, ☆restricted joint movements+bilateral hip dislocation(⇔hurler), claw hand deformities, kyphoscoliosis, and high plasma levels of lysosomal enzymes.
Often fatal in childhood. biochemistry Jun 23, 2020, 8:10 AM HirotoShishido
the first step for de novo pyrimidine synthesisglutamine, ☆carbon dioxide and 2 molecules of ATP are used to form carbamoyl phosphate in a reaction catalized by larbamoyl phosphate synthase Ⅱ in ☆cytoplasm
after initial synthesis in the cytosol, purine and pyrimidine nucleotides are utilized for DNA synthesis in the nucleus biochemistryUWorld SIM2 Jun 21, 2020, 6:10 AM HirotoShishido
phosphatidylinositol 2nd messenger systemThe alpha subunit of the active G protein initially stimulates phospholipase C, which catalyzes the breakdown of membrane-bound inositol phospholipids into 2 second messenger products
– inositol triphosphate (IP3) and diacylglycerol (DAG).
IP3 produces most of its effects by ☆releasing stored calcium from the smooth endoplasmic reticulum.
DAG activates protein kinase C, which phosphorylates downstream regulatory proteins and transcription factors. biochemistrypharmacologyUWorld SIM2 Jun 21, 2020, 5:58 AM HirotoShishido
