diffrentiate between folate and vitamin B12 deficiency↑ homocysteine in both
☆↑ methylmalonic acid only in cobalamin deficiency(cobalamin=cofacter for methylmalonyl CoA mutase)
(methylmalonyl CoA is converted to succinyl CoA with the cofactor vitamin B12. If there is not enough vitamin B12 present, methylmalonyl CoA is alternatively converted to methylmalonic acid) hematologyUWorld Jun 14, 2019, 1:49 AM HirotoShishido
most common cause of inherited hypercoagulability in Caucasiansfactor Ⅴ leiden
mutant factor Ⅴ is resistant to degradation by activated piotein C
Bernard-Soulier syndrome
platelet count↓GPⅠb(Ⅸ/Ⅴ complex)→defect in platelet to vWF adhbsion
→large platelet→↓platelet count hematology Jun 18, 2019, 6:32 AM HirotoShishido
antiphospholipid antibody syndrome
PT,PTTparadoxically show an increase in coagulation time hematology Jun 18, 2019, 7:24 AM HirotoShishido
strage pool disease
defect
medication which has the similar effectdefect in ADP release
clopidogrel(block ADP receptor+prevent expression of Gp Ⅱb/Ⅲa) hematology Jun 18, 2019, 6:52 AM HirotoShishido
Burkitt lymphoma
mantle cell lymphoma
follicular lymphoma
translocationバーはいいよ！(8;14) c-myc activation
ママといい日よ！(11;14) cyclin D1 activation
ロイホは一生いや！(14;18) BCL-2 activation +(DLBCL, diffuse large B-cell lymphoma) hematology Dec 26, 2018, 1:00 AM HirotoShishido
neoplasm associated with BCL-2 overexpressionfollicular and diffuse large B Cell Lymphoma
BCL→antiapoptotic molecule
Bcl-2 keeps the mitochondrial membrane impermeable, thereby preventing ☆cytochrome C release from mitochondria. Bcl-2 overexpression (eg, follicular lymphoma t[14;18])→↓caspase activation→tumorigenesis. geneticshematologyUWorld Sep 17, 2019, 7:50 AM HirotoShishido
treatment and prevention for Rh hemolytic disease of the newbornexchanging the Rh-positive blood with Rh-negative blood
prevention→administration of anti-D IgG to Rh negative pregnant woman during third trimester and eary postpartum period immunologyhematologyobstetrics Sep 25, 2019, 10:46 PM HirotoShishido
