TAP protein
functionTAP(transporter associated with antigen processing) protein transports some of the peptide fragments degraded by proteasome into the endoplasmic reticucum and load onto ☆MHC class Ⅰ molecules
genetic mutation affecting MHC claps Ⅰ polypeptide complex expression(bare lymphocyte syndrome type Ⅰ)
→ulcerative glanulomatous skin lesions and frequent respiratory infeltions ☆despite normal lymphocyte and immunoglobulin levels immunologyUWorld HirotoShishido
how does natural killer cells workuse ☆perforin and granzymes to induce apoptosis of virally infected cells and tumor cells immunology HirotoShishido
staphylococcal toxic shock syndrome(TSS)
pathophysiology, etiology, symptomsTSST-1(superantigen) binds to ☆MHCⅡ and T-cell receptor, resulting in polyclonal T-cell activation
What does HiB(Haemophilus influenzae type B) vaccine contain?capsular polysaccharide(polyribosylribitol phosphate,PRP)
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diphtheria toxoid(to generate an antibody response) immunology HirotoShishido
hyperacute transplant rejection
pathogenesis(occurs within minutes)
pre-existing recipient antibodies react to donor antigen(type Ⅱ hypersensitivity reaction) immunology HirotoShishido
where is HEV in lymph node(high endothelial venules)
dupilmabmonoclonal antibody targenting IL-4 receptor alpha used for allergic disease such as eczema and nasal polyps dermatologyimmunology HirotoShishido
