"neurology" Post in this tag
management for transient ischemic attack(TIA)
Secondary prevention of future stroke includes antiplatelet agents (eg, aspirin, clopidogrel) to prevent thrombus formation and ☆statin therapy (HMG-CoA reductase inhibitor; eg, atorvastatin, rosuvastatin) to reduce atherosclerotic plaque formation. Lifestyle modifications (eg, exercise, tobacco cessation) are also recommended.
neurology
UWorld
HirotoShishido
dominant hemisphere and dominant hand
99% of the right handed→dominant hemisphere is on the left
70% of the left handed→dominant hemisphere is on the left
neurology
rehabilitation
HirotoShishido
complete paralysis
physical examination
anal sensation,motor
bulbocavernosusreflex(BCR)
球海綿体反射
neurology
HirotoShishido
small cell carcinoma
hormone production
ACTH→Cushing syndrome
ADH→SIADH
Antibodies against presynaptic Ca2+ channel→Ach release is affected→weakness on the lower extremities(Lambert-Eaton myasthenic syndrome)
endocrinology
respiratory
neurology
HirotoShishido
normal intracranial calcification
pineal gland, habenula(手綱), choroid plexus, basal ganglia, dentate nuclei
neurology
HirotoShishido
pilocytic astrocytoma
region, histology, characteristics on imaging
(Juvenile) pilocytic astrocytomas usually arise in the ☆cerebellum, brainstem, hypothalamic region, or optic pathways.
Microscopically, pilocytic astrocytomas are well-differentiated neoplasms comprised of ☆spindle cells with hair-like glial processes that are associated with microcysts. These cells are mixed with ☆Rosenthal fibers and granular eosinophilic bodies.
well-demarcated lesion comprised of cystic and solid components (white and red arrows, respectively)
neurology
neurosurgery
UWorld
HirotoShishido
PRL産生腫瘍か非機能性腺腫か
下垂体腺腫の治療の第一選択は,PRL産生下垂体腺腫は薬物療法(ドパミン作動薬:ブロモクリプチン,テルグリド,カベルゴリン),その他の腫瘍(GH産生下垂体腺腫,非機能性下垂体腺腫など)では手術である.一般的にプロラクチン産生下垂体腺腫のプロラクチン値は200ng/mL以上となる(実際には数千もの高値をとることもある).PRL 34.8ng/mLが下垂体茎圧迫による軽度上昇の範囲
neurology
neurosurgery
国試
HirotoShishido
Klüver-Barrera染色
髄鞘(ミエリン)を青く染色するので,大脳白質は青,皮質と基底核の青みは弱い(髄鞘が少ないため).矢印の部位は大脳の内部にあるので基底核(尾状核,被殻,淡蒼球)に含まれ,側脳室に面しているので尾状核
neurology
国試
HirotoShishido
mutation in spinal and bulbar muscular atrophy
SBMA
Kennedy-Alter-Sung syndrome
XR
アンドロゲン受容体蛋白(X染色体長腕)のポリグルタミン異常伸長
neurology
国試
HirotoShishido
女性のDuchenne型筋ジストロフィー症
●Lyon現象
女性では父親由来の遺伝情報が発現した細胞は正常機能を持つが,母親由来の遺伝情報が発現した細胞は病的となる. という現象. 軽症ながら臨床症状を発症することがある.その場合,心筋障害を伴う例が多い.
neurology
国試
HirotoShishido
CAG triplet diseases
Spinal and bulbar muscular atrophy (SBMA)
Machado-Joseph disease(SCA-3)SCA-6
SCA-1,2,7
Dentatorubral pallidoluysian atrophy (DRPLA)
Huntington disease
neurology
国試
HirotoShishido
近位筋萎縮の例外
spinal muscular atrophy (SMA)
type 1= Werdnig-Hoffmann disease
type 3= Kugelberg-Welander disease
☆spinal and bulbar muscular atrophy (SBMA)
→ characterized by ☆gynecomastia
神経原生だが近位筋萎縮
myotonic dystrophy
筋原生だが遠位筋萎縮
neurology
国試
medic media模試
HirotoShishido
early and late onset of Alzheimer's disease
eary→ associated with Amyloid precursor protein(APP) (on chromosome 21)
☆presenilin-1,2
late→ (1 or 2 copies of)Apolipoprotein E epsilon 4 are at high risk
neurology
genetics
UWorld
HirotoShishido
medications which have agonism and antagonism at the opioid receptors
☆nalbuphine, pentazocine
κ opiate receptor agonist and a partial antagonist at the μ opiate receptors within the CNS
pharmacology
neurology
HirotoShishido
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