the difference of mechanism between paclitaxel and vinca alkaloidspaclitaxel(TAXanes)→ ☆hyperstabilize polymerized microtubules in M phase so that mitotic spindle cannot break down(anaphase cannot occur)
(TAX STABILIZE the society)
antitumor antibiotics which induce
free radicalsbleomycin
doxorubicin (can be treated with dexrazoxane, chelating agent to block the formation of iron associated free radicals) oncologypharmacology HirotoShishido
how RAS-MAPK does contribute to gene transcription for growthRas proteins are G-proteins linked to receptor tyrosine kinases in the cell membrane.
Ras-GTP causes a cascade of reactions within the cell, eventually initiating mitogen-activating protein kinase (MAPK). pharmacologyoncology HirotoShishido
Even with adequate treatment of a malignancy, the areas affected by field cancerization remain at higher risk of developing multiple primary malignancies, as seen in this patient. Therefore, patients diagnosed with any of these cancers require comprehensive evaluation and continued surveillance of the at-risk area. pathologyoncologyUWorld HirotoShishido
highly sensitive(>95%) and specific (-100%) marker for melanomaHMB-45(a monoclonal antibody that binds to immature melanosomes found in melanocytic tumors, Human Melanoma Black) dermatologyoncologyUWorld HirotoShishido
