what receptor is affected by decreased ATP during cell injuryNa+-K+ ATPase,
sarcoplasmic reticulum Ca2+-ATPase
→ increased intracellular Na+ and ☆Ca2+ and increased intramitochondrial Ca2+ pathologyUWorld Jun 30, 2020, 3:40 AM HirotoShishido
histopathology of syphilitic lesionat all stages classlcally demonstrate ☆proliferative endarteritis of small vessels with a surrounding plasma cell rich infiltrate
(eg. aortic aneurysm, condyloma lata)
phases of wound healingInflammatory (up to 3 days after wound)
Proliferative (day3- weeks after wound)
☆deposition of granulation tissue and ☆type Ⅲ collagen
Remodeling (1week- 6+months after wound)
☆type Ⅲ collagen is replaced by type Ⅰ collagen
※keloid has both type Ⅰ and Ⅲ collagen
raised, painful, pruritic, ☆extends beyond borders of original wound pathologyUWorld Jun 26, 2020, 4:14 AM HirotoShishido
fibrinoid necrosisImmune vascular reactions (eg, PAN)
type Ⅲ hypersensitivity→ PAN, serum sickness
others→ small vessel vasculitis, hyperacute transplant rejection
Nonimmune vascular reactions (eg,hypertensive emergency, hypertensive nephrosclerosis, preeclampsia) pathology Jun 26, 2020, 3:36 AM HirotoShishido
reversible and irreversible cell injuryreversible
↓ATP →↓ activity of Ca2+ and Na+/K+ pumps→ ☆cellular swelling (earliest morphologic manifestation), ☆mitochondrial swelling, chromatin clumping, plasma membrane changes(eg bleb)
irreversible
Breakdown of plasma membrane→ cytosolic enzymes (eg, troponin) leak outside of cell, influx of Ca2+ → activation of degradative enzymes,
Mitochondrial damage/dysfunction→ loss of electron transport chain= ☆mitochondrial vacuolization→ ↓ATP, apoptosis, rupture of lysosomes→ autolysis pathologyUWorld Jun 26, 2020, 3:23 AM HirotoShishido
