patiromer
mechanism, clinical use, adverse effecta nonabsorbable cation exchange resin that binds colonic potassium in exchange for calcium, trapping potassium within the resin where it is then excreted in the feces.
often used for treatment of ★chronic hyperkalemia. (however, onset of action takes several hours, so it is not recommended as monotherapy in acute hyperkalemia)
GI disturbance, hypercalcemia, hypokalemia, hypomagnesemia
orexin receptor antagonist☆raMELteon
→used for insomnia
☆with the lowest side effect burden in older adults
suvOREXANT
→ OREXin(hypocretin) ANTagonist
recommended in patients with liver disease, limited physical dependance pharmacologyUWorld Mar 22, 2020, 9:41 AM HirotoShishido
medication for weight loss
mechanism, adverse effects・orlistat
inhibit gastric and pancreatic lipase
(significant) GI side effect→ abdominal pain, flatulence, fat soluble vitamin deficiency
the reason why phenytoin trigger neural tube defectchronic phenytoin use changes PH in the gut into 10-12, which reduces folate uptake(optimal PH for folate is 5〜5.5) pharmacologyembryologyOBGY Apr 27, 2019, 12:33 AM HirotoShishido
original combination chemotherapy for Hodgkin lymphomacan be used for the patients who relapse or have allergies to ABVD
ADH V1 and V2 receptorsV2 reabsorb water causing concentration of urine, dilution of body fluids(by inserting aquaporins into collecting duct)
V1 cause contraction of vascular smooth muscles leading to an increase in total peripheral resistance pharmacologyendocrinology May 29, 2019, 12:27 AM HirotoShishido
three types of chronic gout drugsxanthine oxidase inhibitors
-allopurinol
(oxypurinol)
-feboxostat
uricosuric medication
-probenecid
-sulfinpyrazone(not used in Japan)
→☆dosage adjustment for penicillin
(because organic anion transporter(OAT) is inhibited in the proximal convoluted tubule, and inhibits secretion of penicillin)
