acute severe hypertension, HF (with organic nitrate)
safe to use during pregnancy
frequently coadministered with a β-blocker to prevent reflex tachycardia
arteriolar variansodilation is limited by subsequent stimulation of baroreceptors
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☆sympathetic activation
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Compensatory tachycardia (contraindicated in angina/CAD), ☆fluid retention(by the stimulation of RAA axis), headache, angina, drug-induced lupus.
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offset much of the BP lowering effect and limit their long term efficacy
cardiovascular
pharmacology
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