Stem cell disorders involving ineffective hematopoiesis → defects in cell maturation of nonlymphoid lineages.
Caused by de novo mutations or environmental exposure (eg, radiation, benzene, chemotherapy). Risk of transformation to AML.
ringed sideroblast,
Pseudo-Pelger-Huet anomaly- neutrophils with bilobed (“duet”) nuclei. Typically seen after chemotherapy.
☆pitechiae, weakness, recurrent infections
(splenomegaly is uncommon)
azacitidine
(inhibit DNA methyltransferase)
pharmacology
hematology
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