PFK-2(active in fed state) increase the production of fructose-2,6-bisphosphate (from fructose-6-phosphate) which in turn increase the activity of PFK-1→ ↑glycolysis
fasting state→ ↑glucagon→→ ↑fructose bisphosphatase-2, ↓phosphofructokinase-2→ less glycosis, more gluconeogenesis
fed state→ ↑insulin→→ ↓FBPase-2, ↑PFK-2→ more glycosis, less gluconeogenesis
(glycosis→kinase, gluconeo→phosphatase)
biochemistry
UWorld
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