pyruvate dehydrogenase deficiency
lactate dehydrogenase deficiency
findings, management

・pyruvate dehydrogenase deficiency
lactic acidosis, neurologic defects

↑intake of ketogenic nutrients(eg ☆lysine, leucine, high fat content)


・lactate dehydrogenase deficiency
Glycolysis is inhibited in strenuously exercising muscle as muscle cells ☆cannot regenerate NAD+

Consequently, high-intensity physical activity leads to muscle breakdown, pain, and fatigue as insufficient amounts of energy are being produced in the exercising muscle.

biochemistry UWorld