Also known as multidrug resistance protein 1 (MDR1).
Classically seen in adrenocortical carcinoma but also expressed by other cancer cells (eg, colon, liver).
Used to pump out toxins, including chemotherapeutic agents (one mechanism of responsiveness or resistance to chemotherapy over time).
+BBB(disruptions of tight junctions or ☆p-glycoprotein inhibition can improve drug delivery to the CNS),
+apical surface of enterocytes(can limit drug bioavailability by pumping the drug back)
pathology
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