Testing for cold agglutinins can be done at the bedside by drawing blood into an edetate disodium-containing tube and placing it in a ☆cup of ice. Removing the tube after several seconds will reveal clumping/agglutination(turbidity) that resolves as the tube warms.
→intravascular hemolysis
⇔warm agglutinin disease(SLE,CLL)→ ☆extravascular hemolysis
cold→ cold avoidance, rituximab
warm→ steroids, rituximab, splenectomy
hematology
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