↑Proportion of body water
Blood-brain barrier immaturity
→☆↑Distribution of water-soluble drugs(eg aminoglycosides, vancomycin) may necessitate higher mg/kg dose, ↑CNS toxicity
CYP enzyme activity
↓Hepatic glucuronidation
→ ↑Sensitivity to hepatically metabolized drugs
↓Renal blood flow & GFR
→ May require lower doses of renally excreted drugs
pharmacology
pediatrics
UWorld
Optimized studying based on the forgetting curve vastly improves memorization. - What is reminDO?
Memorize
