targeted drug therapyuse of platinum based chemotherapy agents is limited because of severe adverse effects(eg nephrotoxicity, ototoxicity, myelosuppression)
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The addition of anti-epidermal growth factor receptor (anti-EGFR) antibodies on the liposome surface results in an antibody-drug conjugate, allowing the encapsulated drug complex to selectively bind to tumor cells expressing high levels of EGFR, which is often overexpressed in non-small cell lung cancer. oncologypharmacologyUWorld HirotoShishido
highly sensitive(>95%) and specific (-100%) marker for melanomaHMB-45(a monoclonal antibody that binds to immature melanosomes found in melanocytic tumors, Human Melanoma Black) dermatologyoncologyUWorld HirotoShishido
field cancerization(multiple tumors develop independently after after an exposure)
Even with adequate treatment of a malignancy, the areas affected by field cancerization remain at higher risk of developing multiple primary malignancies, as seen in this patient. Therefore, patients diagnosed with any of these cancers require comprehensive evaluation and continued surveillance of the at-risk area. pathologyoncologyUWorld HirotoShishido
the difference of mechanism between paclitaxel and vinca alkaloidspaclitaxel(TAXanes)→ ☆hyperstabilize polymerized microtubules in M phase so that mitotic spindle cannot break down(anaphase cannot occur)
(TAX STABILIZE the society)
antitumor antibiotics which induce
free radicalsbleomycin
doxorubicin (can be treated with dexrazoxane, chelating agent to block the formation of iron associated free radicals) oncologypharmacology HirotoShishido
PD-1, PD-L1 antibodyPD-1(on T cells) →☆pembrolizumab(melanoma), nivolumab(NSCLC, metastatic melanoma)
