oligoarticular(less than 5 joints)
polyarticular(more than 5 joints)
spondyloarthritis
distal interphalangeal predominant (affects joints at the end of the fingers and toes→dactylitis)
arthritis multilans
NSAIDs,(for more severe)sulfasalazine,methotrexate(disease modifying anti-rheumatic drugs,DMARDs)
①when does it appear ②which types of HLA ③other diseases associated with(②) ④what does (②)gene code for①2-3weeks after sexually transmitted infection or gastroenteritis
②HLA-B27
③psoriasis,ankylosing spondylitis
④MHC1 musculoskeletalrheumatology Apr 23, 2019, 10:05 AM HirotoShishido
syndrome→occurs w/ lupus,scleroderma,burger disease,Takayasu disease
asymmetrically rheumatology May 8, 2019, 12:10 AM HirotoShishido
Dermatomyositis factorsgenetic factors→person w/ HLA-DR3 or HLA-DR5
environmental factors→after the exposure to coxsakievirus or specific cancer antigen(ovarian,lung,breast) rheumatology May 7, 2019, 3:22 AM HirotoShishido
IgG4 related diseaseautoimmune pancreatitis
Miculicz disease(dacryoadenitis涙腺炎,sialadenitis唾液腺炎)
idiopathic retroperitoneal fibrosis rheumatology May 6, 2019, 11:49 PM HirotoShishido
DR2 DRiving 2 MULTIPLE(MS) HAY(hay fever) PASTURES(goodpasture) will cause NARCOLEPSY
DR2+3 SLE
DR3+4 DM type Ⅰ
DR4 rheumatoid arthritis
DR3+5 HASHIMOTO is an ODD DoctoR(3,5)
DR8 primary biliary cholangitis immunologyrheumatology Apr 23, 2019, 10:25 AM HirotoShishido
Systemic juvenile idiopathic arthritis=still’s disease
onset at any age, M=F
•once or twice daily fever spikes(>38.5oC)≥ 2d/wk with temperaturere turning below baseline; children
usually acutely unwell during fever episodes
• extra-articular features: erythematous “salmon-coloured” maculopapular rash, lymphadenopathy,
☆hepatosplenomegaly, leukocytosis, thrombocytosis, anemia, serositis
•arthritis may occur weeks to months later rheumatology国試過去3回 Oct 13, 2020, 2:14 AM HirotoShishido
treatment for organ threatning disease in SLEIV cyclophosphamide for serious organ involvement (e.g. cerebritis or lupus nephritis) for clinical features of lupus nephritis rheumatology過去3回国試 Sep 21, 2020, 12:37 AM HirotoShishido
triggers associated w/ lupusgenetic susceptibility,UV radiation,cigarette smoking,bacteria or virus,estrogen,medications("DILE" sulfa drugs, ★hydralazine, isoniazid, methyldopa, minocycline, procainamide, phenytoin, and etanercept (SHIMMPP-E))
these medications are ☆metabolized via phase Ⅱ acetylation in the liver
where does it hurt in the patient with polymyalgia rheumaticapain and (morning)stiffness in proximal muscles(shoulders, hips) rheumatology Dec 7, 2019, 2:44 AM HirotoShishido
