DM muscle and skin symptomsskin→Heliotrope rash(violaceous紫 periorbital),Gottron papules,shawl and face rash(ショール徴候),malar rash
muscle→bilateral weakness,muscle atrophy,tenderness,pain(mostly proximal)
dysphagia rheumatology May 7, 2019, 3:35 AM HirotoShishido
Dermatomyositis factorsgenetic factors→person w/ HLA-DR3 or HLA-DR5
environmental factors→after the exposure to coxsakievirus or specific cancer antigen(ovarian,lung,breast) rheumatology May 7, 2019, 3:22 AM HirotoShishido
PM/DM
which cells goes with which muscle layerpolymyositis→endomysial inflammation with CD8+ T cell
dermatomyositis→perimysial inflammation with CD4+ T cell
(epimysium→ perimysium→ endomysium→ sarcolemma(cell membrane)) rheumatology May 7, 2019, 3:18 AM HirotoShishido
IgG4 related diseaseautoimmune pancreatitis
Miculicz disease(dacryoadenitis涙腺炎,sialadenitis唾液腺炎)
idiopathic retroperitoneal fibrosis rheumatology May 6, 2019, 11:49 PM HirotoShishido
OA,RA
Which pharyngeal joints are affected?OA→DIP(Heberden nodes),PIP(Bouchard node),and first CM
oligoarticular(less than 5 joints)
polyarticular(more than 5 joints)
spondyloarthritis
distal interphalangeal predominant (affects joints at the end of the fingers and toes→dactylitis)
arthritis multilans
NSAIDs,(for more severe)sulfasalazine,methotrexate(disease modifying anti-rheumatic drugs,DMARDs)
DR2 DRiving 2 MULTIPLE(MS) HAY(hay fever) PASTURES(goodpasture) will cause NARCOLEPSY
DR2+3 SLE
DR3+4 DM type Ⅰ
DR4 rheumatoid arthritis
DR3+5 HASHIMOTO is an ODD DoctoR(3,5)
DR8 primary biliary cholangitis immunologyrheumatology Apr 23, 2019, 10:25 AM HirotoShishido
reactive arthritis
①when does it appear ②which types of HLA ③other diseases associated with(②) ④what does (②)gene code for①2-3weeks after sexually transmitted infection or gastroenteritis
②HLA-B27
③psoriasis,ankylosing spondylitis
④MHC1 musculoskeletalrheumatology Apr 23, 2019, 10:05 AM HirotoShishido
symptoms and joint findings of osteoarthritis and rheumatoid arthritisOA
no swelling,sharp ache
morning stiffness less than an hour(come back at the end of the day)
☆synovial fluid noninflammatory, dislodged pieces of cartilage and subchondral bone, joint space narrowing
RA
painful swelling
morning stiffness more than an hour
improve with use(Lambart Eaton)
increased synovial fluid(inflammtory) rheumatologymusculoskeletal Apr 7, 2019, 1:14 AM HirotoShishido
IgA vasculitis(Henoch Schonlein purpura, HSP)
triad+1・skin (palpable purpura on the buttocks and lower extremities, 下腿伸側左右対称隆起性紫斑)
・GI (intermittent severe abdominal pain, upper and lower GI bleeding, intussusception)
・joints (migratory arthralgias and arthritis in large joints of the lower extremities)
・kidneys (IgA nephropathy)
