which malignancy is xeroderma pigmentosum characterized by a preposition to?malignant melanoma geneticsdermatology Sep 17, 2019, 5:06 AM HirotoShishido
Kaposi sarcoma
symptomsneoplasm of endothelial cells
can affect GI tract(black stool) and lungs dermatology Sep 8, 2019, 11:40 PM HirotoShishido
Picture
where does it commonly appearverruca plana (juvenilis)
(青年性)扁平疣贅
Silvery-white scaling plaques,topical corticoSteroids
Munro microabscesses (neutrophils)
Auspitz sign (pinpoint bleeding when scales are scraped off)
PUVA(phototherapy)
arthritis(DIP関節)
koebner phenomenon(正常部位を刺激すると病変部位と同様の変化を起こす isomorphic response)
(b)vitamin D3→ ¥calcipotriene, callitriol
48 ターンオーバー45→3日(45+3) dermatologyAmboss level4 Oct 18, 2018, 8:19 AM HirotoShishido
What predispose the patient to developing BRAF mutation, leading to malignant melanomaFormation of covalent bonds between adjacent pyrimidine bases
DNA lesions are caused by exposure to UV radiation and form bulky helix distortions that interfere with DNA replication. geneticsdermatologyAmboss level4 May 8, 2020, 12:32 PM HirotoShishido
scleroderma
histopathological findings☆dermal layer expansion due to diffuse deposition of collagen (eosinophilic connective tissue), resulting in ☆atrophy of the intradermal adipose tissue and dermal appendages (ie, hairfollicles, glands). dermatologyrheumatologyUWorld Apr 1, 2020, 11:39 AM HirotoShishido
common type of melanoma in Asians and Africansacral lentiginous(末端黒子型)
sporothrix schenckii
transmissionspores are traumatically introduced into the skin, typically by ☆a thorn("rose gardener's disease") microbiologydermatologyUWorld Mar 25, 2020, 9:40 PM HirotoShishido
highly sensitive(>95%) and specific (-100%) marker for melanomaHMB-45(a monoclonal antibody that binds to immature melanosomes found in melanocytic tumors, Human Melanoma Black) dermatologyoncologyUWorld Apr 26, 2020, 5:20 AM HirotoShishido
cells of origin to glomus tumormodified smooth muscle cells of the ☆thermoregulatory glomus body
(The role of the glomus body is to shunt blood away from the skin surface in cold temperatures in order to prevent heat loss, and to direct blood flow to the skin surface in hot environments to facilitate the dissipation of heat.) dermatologyUWorld Apr 25, 2020, 9:37 AM HirotoShishido
management for this conditionxerosis
use lukewarm water rather than hot and neutral or acidic clensers rather than alkaline soaps when bathing+ moisturlize immediate after bathing to prevent excessive skin water loss dermatologyUWorld SIM2 Jun 20, 2020, 8:34 AM HirotoShishido
what causes blanching in the patient with burn☆Release of histamine and other preformed vasoactive mediators from mast cells in the minutes following a burn leads to dilation of superficial skin capillaries.
This results in blanching erythema (ie, temporary whitening with pressure due to capillary collapse) that extends to the area surrounding the initial burn.
clinical use/ mechanism of action of imiquimodmany common dermatologic disorders associated with abnormal cell proliferation, including ☆anogenital warts (human papillomavirus virus infection), superficial basal cell carcinoma, and actinic keratosis
activation of ☆toll-like receptor 7, which upregulates the proinflammatory transcription factor nuclear factor-kappa B (NF-KB)
→ enhanced immune-mediated killing of aberrant cells dermatologypharmacologyUWorld May 30, 2020, 3:51 AM HirotoShishido
