Activated T cells in GBS attack and demyelinate Schwann cells, which normally function to myelinate axons in the peripheral nervous system. RxNeurology TakTak
Phenytoin increases sodium channel inactivation, thereby decreasing the flux of sodium ions across the neuronal membrane. This action prevents rapid repetitive firing of the axon, often a mechanism of seizure activity. RxNeurologyPharmacology TakTak
Amantadine was historically used to treat influenza but is now primarily used to treat mild cases of Parkinson disease that do not inhibit daily activities. It is believed to increase dopamine release and inhibit dopamine reuptake. RxNeurologyPharmacology TakTak
Chronic alcohol use can cause thiamine deficiency, which can lead to Wernicke-Korsakoff syndrome. Patients with Wernicke-Korsakoff syndrome commonly present with memory problems, confusion, nystagmus, and unsteady gait.
Wernicke-Korsakoff syndrome is characterized by mammillary body degeneration. RxNeurology TakTak
Huntington disease is an autosomal dominant CAG trinucleotide repeat disease that presents with progressive chorea, behavioral changes, and dementia. RxNeurology TakTak