heparin-induced trombocytopenia and thrombosis(HITT)
onset, mechanism of aggregation+thrombocytopenia

5-10days following exposure to heparin products

the generation of IgG antibodies to ☆heparin and platelet factor 4(PF4) → Fc component of the IgG than binds to additional platelets→ widespread platelet activation

clearance of antibody-coated platelets by ☆splenic macrophages.

hematology UWorld