the enterocytes contain ☆clear or foamy cytoplasm (lipid laden enterocytes, arrows) which is more prominent at the tips of the villi
Autosomal recessive. Mutation in gene that encodes microsomal transfer protein (MTP). Chylomicrons, VLDL, LDL absent. Deficiency in ApoB-48, ApoB-100.
manifests during the first year of life with symptoms of ☆malabsorption
later with deficiency of fat-soluble vitamins (particularlyvitamin E) and essential fatty acids. +acanthocytes, progressive ataxia, retiniti
gastrointestinal
UWorld
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