which cytoskeletal elements are used as an immunohistochemical stain to detect adenocarcinoma of the esophaguscytokeratin→ intermediate filaments(maintaining cell structure) biochemistry HirotoShishido
the differences between
Hunter syndrome and Hurler syndrome(mucopolysaccharidoses, MPS)
リピドーシスで、cherry red spot 起こすもの(lysosomal strage disease)
Niemann Pick disease
Tay Sachs disease
metachromatic leukodystrophy(arylsulfatase A) biochemistry HirotoShishido
What substance get accumulated in the setting of tissue hypoxiaWithout oxidative phosphorylation, the body increases glycolysis to generate ATP anaerobically, which produces excess pyruvate and ¥NADH.
(NAD+ is generally used in catabolic processes to carry reducing equivalents away as NADH)
The increased NADH/NAD+ ratio in this setting favors the conversion of excess pyruvate into lactate to regenerate NAD+. biochemistryAmboss level4 HirotoShishido
specific symptom for cystic fibrosis(CF), cause of deathalmost all full-term infants with meconium ileus( by inspissated=dehydrated meconium)are eventually diagnosed with CF
deficient enzyme in maturity-onset diabetes of the young(MODY)
characteristics(若年発症成人型糖尿病)
glucokinase(production of glucose-6-phosphatase from glucose)
mild hyperglycemia that often worsens with pregnancy-induced insulin resistance
☆can maintain very good glycemic control with dietary modification only
patients with MODY are typically younger and nonobese, and the condition is nonprogressive, even without the treatment
not associated with an elevated risk of long term diabetic complications endocrinologybiochemistryUWorld HirotoShishido
