symptoms develop on Monday with re-exposure, due to loss of tolerance. The most severe consequence occurs when compensatory vasoconstriction is unopposed in critical areas such as the coronary vessels, leading to nonatherosclerotic-related cardiac ischemia cardiovascularpharmacology HirotoShishido
diseases associated with type Ⅲ hypersensitivityPAN, PSGN, SLE, serum sickness, arthus reaction(infrequently reported after vaccinations containing diphtheria and tetanus toxoid)
hypertensive emergency
medications commonly employed(blood pressure >180 mm Hg systolic and/or >120 mm Hg diastolic plus end-organ involvement)
nitroprusside(metabolized to NO, ☆venodilate=vesodilate)
labetalol(α,β-blocker)
☆fenolDOPAM(dopamine-1 receptor agonist, ☆renal vasodilation is particulary prominent) pharmacologycardiovascularUWorld HirotoShishido
β1 blocker effect on
HR, SV, CO, MAP↓HR by negative inotropic effect
