Wernicke encephalopathy
on imaging,symptoms, managementincieased MRI T2 FLAIR signal involving the ☆mammillary bodies, →Confusion
dorsomedial thalami, →Amnesia
tectal plate,
periaqueductal area,
(around the third ventricle)
+Ataxia,Nystagmus,Ophthalmoplegia
(CAAN Of beer)
intravenous thamine should be administered before infusion of glucose-containing fluids in at-risk patient because ☆glucose can deplete the last remaining stores of thiamine neurologypsychiatryUWorld HirotoShishido
Huntington disease
pathogenesis, symptoms, mechanism of silencingexpansion of CAG repeatIN(more than 36 repeat)
Caudate loses Ach and Gaba(GABA)
especially, INdirect way is affected
(↓GPi activity)
chorea, athetosis, psychiatric symptoms→ highly prevalent and may occur prior to the onset of chorea, including ☆phychosis, depression, anxiety, apathy
dementia can be seen later in the disease course and characterized by a prominent execuive dysfunction
