expansion of CAG repeatIN(more than 36 repeat)
Caudate loses Ach and Gaba(GABA)
especially, INdirect way is affected
(↓GPi activity)
chorea, athetosis, psychiatric symptoms→ highly prevalent and may occur prior to the onset of chorea, including ☆phychosis, depression, anxiety, apathy
dementia can be seen later in the disease course and characterized by a prominent execuive dysfunction
↓histone acetyltransferase→ ☆↑histone deacetylase→ ↓transcription of neurotrophic factors
neurology
psychiatry
UWorld
Optimized studying based on the forgetting curve vastly improves memorization. - What is reminDO?
Memorize
