scleroderma
histopathological findings☆dermal layer expansion due to diffuse deposition of collagen (eosinophilic connective tissue), resulting in ☆atrophy of the intradermal adipose tissue and dermal appendages (ie, hairfollicles, glands). dermatologyrheumatologyUWorld HirotoShishido
common type of melanoma in Asians and Africansacral lentiginous(末端黒子型)
sporothrix schenckii
transmissionspores are traumatically introduced into the skin, typically by ☆a thorn("rose gardener's disease") microbiologydermatologyUWorld HirotoShishido
highly sensitive(>95%) and specific (-100%) marker for melanomaHMB-45(a monoclonal antibody that binds to immature melanosomes found in melanocytic tumors, Human Melanoma Black) dermatologyoncologyUWorld HirotoShishido
cells of origin to glomus tumormodified smooth muscle cells of the ☆thermoregulatory glomus body
(The role of the glomus body is to shunt blood away from the skin surface in cold temperatures in order to prevent heat loss, and to direct blood flow to the skin surface in hot environments to facilitate the dissipation of heat.) dermatologyUWorld HirotoShishido
management for this conditionxerosis
use lukewarm water rather than hot and neutral or acidic clensers rather than alkaline soaps when bathing+ moisturlize immediate after bathing to prevent excessive skin water loss dermatologyUWorld SIM2 HirotoShishido
what causes blanching in the patient with burn☆Release of histamine and other preformed vasoactive mediators from mast cells in the minutes following a burn leads to dilation of superficial skin capillaries.
This results in blanching erythema (ie, temporary whitening with pressure due to capillary collapse) that extends to the area surrounding the initial burn.
clinical use/ mechanism of action of imiquimodmany common dermatologic disorders associated with abnormal cell proliferation, including ☆anogenital warts (human papillomavirus virus infection), superficial basal cell carcinoma, and actinic keratosis
activation of ☆toll-like receptor 7, which upregulates the proinflammatory transcription factor nuclear factor-kappa B (NF-KB)
→ enhanced immune-mediated killing of aberrant cells dermatologypharmacologyUWorld HirotoShishido
