vibrio vulnificus
transmission, risk factors, manifestationstransmission→ ingestion of raw oysters or ☆wound infection (★)during recreational activities (eg, sailing) or raw seafood handling
risk factors→ ☆iron overload, (★)liver diseases (eg, hemochromatosis → particularly great risk as free iron acts as an exponential growth catalyst)
manifestations→ cellulitis(hemorrhagic bullae, ☆necrotizing fasciitis→sudden onset of severe pain and swelling at the site of wound often caused by GAS), septicemia infectious diseasedermatologyUWorld step2CK Mar 6, 2020, 11:09 PM HirotoShishido
severe(significant scarring)→ ☆oral isotretinoin(☆absolutely contraindicated in pregnancy)→ vitamine A supplementation is ☆not indicated for pregnant woman unless she lives in an area where deficiency is public health problem→ can cause spontaneous abortion and fetal defects microbiologydermatologyUWorld Dec 13, 2019, 11:44 PM HirotoShishido
Picture"spaghetti and meatballs" appearance
→tinea versicolor (less pruritic than dermatophytes) microbiologydermatology Oct 16, 2019, 5:25 AM HirotoShishido
Celiac disease→ ☆caused by subepidermal immunoglobulin A deposition, and ☆intraepidermal lymphocyte
*pathogenesis of dermatitis herpetiformis
→ IgA cross-react with epidermal transglutaminase→ microabscess containing fibrin and neutrophils at the dermal paplllae tips microbiologydermatologyUWorld Oct 13, 2019, 12:39 AM HirotoShishido
Picture
other manifestationsshagreen patch→tuberous sclerosis
what is the common pathophysiology between CDKN2A, Rb, TP53(gene)code the products which block cell-cycle progression past the G1/S checkpoint
CDKN2A→ melanoma, pancreatic cancer
mutation of chromosome 9q21 is associated with dysplastic nevus syndrome, (nests of nevomelanocytes with ☆hyperchromatic nuclei and bridging with nests in neighboring rete pegs) and patient with this mutation and greater than 3 first degree relatives with melanoma have 75% chance of melanoma in the lifetime geneticsdermatologyUWorld SIM2 Sep 19, 2019, 4:33 AM HirotoShishido
which malignancy is xeroderma pigmentosum characterized by a preposition to?malignant melanoma geneticsdermatology Sep 17, 2019, 2:06 AM HirotoShishido
psoriasis histopathologyacanthosis(epidermal hyperplasia) with parakeratotic scaling(retention of nuclei in staratum corneum)
