what urinary disease the patient with Crohn disease is predisposed to?urinary stone
Crohn disease can develop fat malabsorption, leading to the increased lipids in the large intestine. These lipids can compete with oxalate for calcium binding in the GI tract, thereby causing decreased formation of calcium-oxalate aggregates (which are eliminated) and increased amounts of free oxalate (which is reabsorbed). Oxalate then must be eliminated in the urine at high concentrations, which can lead to the formation of calcium oxalate kidney stones. gastrointestinal HirotoShishido
giardia
etiologycolonization of the gut by Giardia trophozoites results in small bowel inflammation and villous atrophy, which reduces absorptive capability gastrointestinalmicrobiology HirotoShishido
biological therapy for IBDanti TNF-α(infliximab)
anti IL-12/23(ustekinumab)
anti JAK(tofacitinib)
anti S1P(sphingosine 1 phospate)(ozanimod)→affect liver and heart
anti α4β7 integrin(vedolizumab) pharmacologygastrointestinal HirotoShishido
Hirschsprung disease
findings“squirt sign.” In this condition, failure to pass stool results in increased pressure proximal to the obstruction which is relieved by rectal examination, leading to forceful evacuation of stool gastrointestinal HirotoShishido
pathophysiology of duodenal atresia, jejunal and ileal atresiaduodenal→ failure to recanalize
amylase and lipase in chronic pancreatitisamylase and lipase may or may not elevated
(almost always elevated in acute pancreatitis) gastrointestinal HirotoShishido
what is effective for prevention of colorectal cancerdaily aspirin therapy
Trials have shown that daily aspirin therapy is associated with reduced risk of colon cancer. (It is important to note that selective COX-2 inhibitors, such as celecoxib, increase the risk of cardiovascular disease and should not be used in the prevention of colon cancer.) gastrointestinal HirotoShishido
three types of adenomatous polypsvillous(malignant)
