Wernicke encephalopathy
on imaging,symptoms, managementincieased MRI T2 FLAIR signal involving the ☆mammillary bodies, →Confusion
dorsomedial thalami, →Amnesia
tectal plate,
periaqueductal area,
(around the third ventricle)
+Ataxia,Nystagmus,Ophthalmoplegia
(CAAN Of beer)
intravenous thamine should be administered before infusion of glucose-containing fluids in at-risk patient because ☆glucose can deplete the last remaining stores of thiamine neurologypsychiatryUWorld Jun 9, 2019, 3:52 AM HirotoShishido
Huntington disease
pathogenesis, symptoms, mechanism of silencingexpansion of CAG repeatIN(more than 36 repeat)
Caudate loses Ach and Gaba(GABA)
especially, INdirect way is affected
(↓GPi activity)
chorea, athetosis, psychiatric symptoms→ highly prevalent and may occur prior to the onset of chorea, including ☆phychosis, depression, anxiety, apathy
dementia can be seen later in the disease course and characterized by a prominent execuive dysfunction
