☆salicylate, TCAs
Salicylate is lipophilic and readily passes into the tissues. Therefore, sodium bicarbonate helps treat salicylate toxicity in two ways.
①bicarbonate binds to free hydrogen ions, facilitating the conversion of lipophilic salicylic acid to lipophobic salicylate ion which are trapped within the bloodstream
②bicarbonate alkanizes the urine, increasing lipophobic salicylate which ☆reduces renal tubular reabsorption
pharmacology
UWorld
Optimized studying based on the forgetting curve vastly improves memorization. - What is reminDO?
Memorize
