decreased numbers of functional acetylcholine receptors at the neuromuscular junction
→ The decrease in the number of available cation channels ☆reduces the end plate potential following acetylcholine release.
→ Because the threshold potential is not reached, the muscle cells do not depolarize.
(Synaptic concentrations of acetylcholine are unaffected, unlike in botulism or Lambert-Eaton syndrome.)
neurology
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