clonal mast cell proliferation occurs in the bone marrow, skin, and other organs→ Mast cell proliferation often is associated with mutations in the ☆KIT receptor tyrosine kinase.
Excessive histamine release from degranulation of mast cells mediates many of the symptoms of the disease, such as ☆syncope, flushing, hypotension, pruritus, and urticaria.
In addition, histamine induces ☆gastric acid secretion, which can lead to gastric ulceration.
gastrointestinal
dermatology
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